Formulating in the second half of the 19th century the definition of life as “a way for the existence of protein bodies,” Friedrich Engels, one of the founders of Marxist theory, knew little about lipids. Meanwhile, it was due to these persistent “hydrophobes” that nascent life was able to isolate itself from the surrounding chaos and create the inner world of the first cellular structures. Over the past 30–40 years, the lipidology has gone through an unprecedented path of development. The initial view of lipids as passive structural components of biological membranes is a thing of the past. Modern science considers the lipid bilayer as an equal participant in various biochemical processes, a structurally heterogeneous “smart” ocean that controls not only the functioning of the proteins embedded in it, but also the logistics of numerous membrane-bound processes optimized during evolution. As Aphrodite is born from the foam of sea waves, the lipid ocean produces a huge number of important biological regulators – inositol-1,4,5-triphosphate, diacylglycerol, numerous derivatives of fatty acids and free fatty acids themselves, endocannabinoids, sphingosine-1-phosphate, ceramides , many of which have their own receptors and without which it is impossible to imagine the life of a cell.

You can talk about all this for a long time – like the tales of “A Thousand and One Nights,” but the author will try to keep within the allotted time.

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